Linear and whorled nevoid hypermelanosis associated with neurological manifestations.

DOI:

https://doi.org/10.26326/2281-9649.30.3.2134

How to Cite

Landeta-Sa A.P., Escandón-Pérez S., Comonfort-Palacios V., Cazarín-Barrientos J., Jaramillo-Manzur S.C. 2020. Linear and whorled nevoid hypermelanosis associated with neurological manifestations. Eur. J. Pediat. Dermatol. 30 (3):148-52. 10.26326/2281-9649.30.3.2134.

Authors

Landeta-Sa A.P. Escandón-Pérez S. Comonfort-Palacios V. Cazarín-Barrientos J. Jaramillo-Manzur S.C.
pp. 148-152

Abstract

Linear and whorled nevoid hypermelanosis (LWNH) is an extremely rare pigmentary mosaicism. It is characterized by hypermelanic macules that follow a Blaschko’s lines pattern. The disease has been found to be associated with the presence of trisomy 4, 7, 13, 14, 18, 20 and chromosome X-linked disorders involving mutations at the Xp21-p22 locus. However, LWNH usually presents as mosaicism. Only 16 to 31% of the cases are associated with neurological and cardiac disorders. Here is reported the case of a 6-year-old female patient with a history of generalized absence seizures and sleep disorders, that were associated with LWNH.

Keywords

Hypermelanosis, Nevoid, Linear, Spiral, Blaschko, Inherited shin disorder