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A newborn baby girl was hospitalized in the Neonatology Institute with diagnosis of epidermolysis bullosa. There were not bullous, acquired or congenital disorders in her family history. Her parents did not present large epidermal nevi. Her blisters were present since birth. There were a few intact blisters with flaccid roof, many eroded, not exuding nor bleeding areas with detached epidermal collarettes (Fig. 1 and box) and large erythematous areas close to cutaneous areas without evident alterations. We diagnosed bullous pyoderma and prescribed ceftriaxone 50 mg/kg per day, leading to significant improvement after twelve hours. The indexes of inflammation were normal and five days later the patient was discharged. Twenty days later at the control examination, besides flaccid blisters on the right foot, there was slight erythema and generalized scaling (Fig. 2 and box), leading to the final diagnosis of epidermolytic hyperkeratosis.