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Acne vulgaris is a chronic inflammatory disease of the pilo-sebaceous follicle, influenced by hormonal factors. The word "acne" comes from the Greek and it means "to flourish", and thus has the same meaning of exanthem. From the original "akm" became "akn", due to a mistake of transcription of the copiers of Aezio. The word "vulgaris" refers to the fact that is the most frequent form of acne, as pemphigus vulgaris, verruca vulgaris and pyoderma vulgaris are the most frequent forms in the group of respectively pemphigus, warts and pyoderma. At the end of this chapter we will mention the other, less frequent form of acne [...].