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The Author describes a 2-year-old girl with preexisting urticaria pigmentosa who developed erythema multiforme-like eruption after starting paracetamol. There were persistent annular and confluent erythematous lesions and bullae over the face, body and extremities. Histopathologic examination with toluidine blue staining of a skin biopsy specimen taken from a bullous lesion showed a dense mast cell infiltrate. The author suggests a relationship between the occurrence of erythema multiforme-like eruption in this child with urticaria pigmentosa and paracetamol treatment.