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Acute generalized exanthematous pustulosis (AGEP) is a rare reaction related to various causes; in most cases, it is a drug-induced reaction. AGEP can occur at any age but is seldom described in children. In this article, we describe an AGEP case in a ten-day-old patient suspected to be caused by erythromycin, cefotaxime and ampicillin. Until now, according to our knowledge, this is the first pulished case of AGEP in a newborn.