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Erythema dyschromicum perstans (EDP) is a pigmentary disorder characterized by blue-brown or gray macules in dark-skinned individuals, that are distributed symmetrically on the trunk and proximal extremities. Generalized EDP is relatively rare. Its etiology has remained obscure and no effective treatment is currently available. Here, we report a Chinese female with generalized EDP, presumably caused by the oral antifungal drug griseofulvin, that affected more than 90% of her body surface area.