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In a study aimed at monitoring the cutaneous lesions of subjects with epidermolysis bullosa (EB), in order to precociously diagnose skin cancer, we investigated the distribution of melanocytic nevi in 13 subjects with epidermolysis bullosa dystrophicans recessiva (EBDR). Six subjects with EBDR presented peculiar melanocytic nevi. The latter were acquired, but large sized, eruptive, punctiform and localized on previous blisters. These nevi, which have been reported in other bullous disorders, are not expression of an increased trend to produce nevi in subjects with EBDR. In fact, the latter present a decreased number of melanocytic nevi as compared with normal controls.